Research – University of Copenhagen

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LIFEPHARM > Research

Research


The purpose of the Novo Nordisk-Life In Vivo Pharmacology Centre (LIFEPHARM) is to strengthen research and education at KU-SUND in the area of In Vivo Pharmacology and Toxiocology.

On-going research projects as per 1 Sept. 2010: 

Post doc projects:

"Oxidative stress as a mediator of endothelial dysfunction - identification and analysis of biomarkers", by Alan S.N. Mortensen. Post doc initiated Sept. 2010. Finalized

"In vivo pharmacology and cardiovascular diseases", by Malene Muusfeldt Birck. Post doc initiated 1. Feb. 2011. Finalized

"Next generation Natriuretic peptides: Chronic heart failure model in minipig", by Ingrid Hunger, Post doc initated 1 July 2012. Finalized

"Analytical pharmacology and toxicology", by Anis Arnous, Post doc initated 1 March 2013. Finalized

"Molecular pharmacology and toxicology", by Gry Freja Skovsted, Post doc initiated 1 November 2014.

"Analytical biochemistry", by Anne Marie Schou-Pedersern, Post doc initiated 1 March 2015.

"Veterinary pharmacology and toxicology", by Liselotte Bruun Christiansen. Post doc inititated 1 January 2016.

PhD Projects:

Start 2010
"Applicability of chronic inflammation models for mechanistic in vivo studies", by Anne Deen Christensen. Supervisors: Søren Skov, KU-LIFE, Claus Haase, Novo Nordisk. PhD fellowship initiated 15 Dec. 2010. Submitted 14 Dec. 2013. PhD defence: 28 April 2014.

Start 2011
"Development and characterization of a diabetic and atherosclerotic rodent animal model", by Ida Rune Sørensen. Supervisors: Axel Kornerup-Hansen, KU-LIFE, Bidda Rolin & Berit Christoffersen, Novo Nordisk. PhD fellowship initiated 1/1 2011. Finalized

"Neonatal vitamin C deficiency and impaired brain development: A dose-response study", by Stine Hasselholt Andersen. Supervisors: Jens Lykkesfeldt & Pernille Tveden-Nyborg, KU-LIFE . PhD fellowship initiated in 1 February 2011. Finalized

"Development and characterization of an atherosclerotic minipig model", by Trine Pagh Ludvigsen. Supervisors: Lisbeth Høier Olsen, KU-LIFE, Henrik Duelund Pedersen and Berit Ø. Christoffersen, Novo Nordisk. PhD fellowship initiated 1 July 2011. Finalized

" The piroxicam accelerated colitis model in IL-10k.o. mice as a tool to discover and characterize novel therapeutics in IBD", by Kristine Holgersen. Supervisors: Axel Kornerup Hansen, KU-LIFE, Thomas Lindebo Holm and Helle Markholst, Novo Nordisk. PhD fellowship initiated 15 Sept. 2011. Finalized

Start 2012
"Predictive value of murine DTH Monoarthritis for rehumatoid Arthritis (RA)", by Sara Marie Atkinson. Supervisors: Søren Skov, KU-SUND, Anneline Nansen, Novo Nordisk. PhD fellowship initated 1 March 2012. Finalized Dec. 2015.

"Relative importance of liver and kidney in the clearance of rFVIIa", by Bill Vestergaard. Supervisors: Jens Lykkesfeldt, KU-SUND, Henrik Agersø, Novo Nordisk. PhD fellowship initiated 1 March 2012. Finalized March 2016.

"New In Vivo cardiovascular biomarkers in an animal model of chronic mitral regurgitation", by Maria Josefine Reimann. Supervisors: Lisbeth Høier Olsen, KU-SUND, Jacob Eifer Møller, Rigshospitalet, Jens Häggström, SLU Uppsala, Sweden. PhD fellowship initiated 1 April 2012

"Metabolic changes induced in non-diabetic rats following chronic hyperinsulinaemic hypoglycaemia", by Vivi F.H. Jensen. Supervisors: Jens Lykkesfeldt, KU-SUND, Ingrid Bøgh Brück, Novo Nordisk. PhD fellowship initiated 1 April. 2012. Finalized October 2015

"Inducing gut regulatory immunity in early life to treat or prevent inflammatory disease later in life", by Katja Maria Bangsgaard Bendtsen. Supervisors: Axel Kornerup Hansen, KU-SUND, Kirsten Dahl, Novo Nordisk, Kerstin Skovgaard, DTU. PhD fellowship initiated 1 June, 2012. Finalized June 2016.

"Microdialysis as a tool to determine drug concentration of infection sites in lung", by Lisa Amanda Holm Rottbøll. Supervisor: Christian Friis, KU-SUND. PhD fellowship initiated 1 June, 2012. Finalized September 2015.

"Effect and mode of action of liraglutide intervention on hyperglycaemia mediated oxidative stress in diabetic and diabetic complications animal models", by Karen Ekkelund Petersen. Supervisor: Jens Lykkesfeldt, KU-SUND, Kirsten Raun & Günaj Rakipovski, Novo Nordisk. PhD fellowship initiated 1 November, 2012.

Start 2013
"Comparative analysis of zebra fish and rodent IBD disease models", by Simon Haarder. Supervisors: Kurt Buchmann, KU-SUND, Per Kania & Poul Hyttel, KU-SUND, Thomas Lindebo, Novo Nordisk. PhD fellowship initated 1 January 2013.

"Characterization of the immune respons to coagulation factor VII in a newly established haemophilia A rat; a model for studies on the mechanism of inhibitor formation in haemophilia A", by Karin Maria Löfgren. Supervisors: Søren Skov, KU-SUND, Bo Wiinberg, Novo Nordisk. PhD fellowship initiated 1 February, 2013.

"Characterization of real time in-vivo coagulation and clot formation by fluorescence microschopy in haemophilia treatments", by Caroline Røddik. Supervisors: Jens Lykkesfeldt, KU-SUND, Christian Sommer, Novo Nordisk, Pernille Tveden-Nyborg, KU-SUND. PhD fellowship initiated 1 June, 2013. Finalized February 2016.

"The specificity of regulator cells in relation to Type 1 diabetes", by Pernille Kihl. Supervisors: Axel Kornerup Hansen, KU-SUND, Matthias von Herrath, Novo Nordisk Seattle, Karsten Buschard, Bartholin Institute. PhD fellowship initiated 1 June, 2013.

"Cognitive and emotional consequences of diet-induced obesity in rats", by Alessandro Virtuoso. Supervisors: Dorte Bratbo Sørensen, Pernille Tveden-Nyborg, Bjørn Forkman, KU-SUND, David Alexander Sarruf, Novo Nordisk. PhD fellowship initiated 1 August, 2013.

"Development and characterization of induced haemarthrosis in the FVIII knockout rat as a mode of haemarthrosis in human haemophilia A", by Kristine Rothaus Sørensen. Supervisors: Axel Kornerup Hansen, KU-SUND, Lise Nikolic Nielsen, Kirstine Roebstorff, Novo Nordisk, Søren Skov, KU-SUND. PhD fellowship initiated 1 November, 2013.

Start 2014
”The high fat fed guinea pig as a model for human dyslipidemia and pre-diabetes”, by David Høilund Ipsen. Supervisors: Jens Lykkesfeldt, KU-SUND, Bidda Rolin, Günaj Rakipovski, Novo Nordisk. PhD fellowship initiated 1 January 2014.

"The impact of neonatal Fc receptor and disease processes on in vivo idstribution of biopharmaceuticals using advanced imaging technologies", by Laura Kofoed Hvidsten Ørstrup. Supervisors: Jens Lykkesfeldt, KU-SUND, Peter Thygesen, Maj Petersen, Novo Nordisk. PhD fellowship initiated 1 May 2014.

"Characterization of diabetic nephropathy in a minipig model of dyslipidemia, hyperglycemia and hypertension", by Rikke Lindgaard Thomsen. Supervisors: Lisbeth Høier Olsen, KU-SUND, Henrik Duelund Pedersen & Berit Christoffersen, Novo Nordisk. PhD fellowship initiated 1 September 2014.

Start 2015
"Mechanisms of neuronal damage induced by vitamin C de-ficiency" by Stine Normann Hansen. Supervisors: jens Lykkesfeldt, Pernille Tveden-Nyborg, KU-SUND. PhD fellowsihp initiated 1 February  2015.

"Characterization of the natriuretic peptide system in a dietinduced obese atherosclerotic minipig model" by Camilla Schumacher-Petersen. Supervisors: Lisbeth Høier Olsen, KU-SUND, Henrik Duelund Pedersen, Novo Nordisk, Nora Elisabeth Zois, Dept. og Clinical Biochemistry, Rigshospitalet. PhD fellowship initated 1 March 2015.

"Refining humane endpoints of long term studies: Using murine species-specific behaviours to assess reduced welfare in the home cage of mice and rats" by Karen Gjendal. Supervisors: Dorte Bratbo Sørensen, KU-SUND, Jan Lund Ottesen, Novo Nordisk, Anna Olsson, Inst. for molecular and cell biology, Portugal. PhD fellowship initiated 1 May 2015.

"Unraveling disease mechanisms in the diabetic heart" by Simone Krog Christensen. Supervisors: Lisbeth Høier Olsen, KU-SUND, Henrik Duelund Pedersen, Novo Nordisk, Jacob Eifer Møller, Odense University Hospital. PhD fellowship initiated 1 October 2015.

"Characterization of immune complex formation and elimination following administration of human antibodies to rats. Establishment of a possible correlation with pathological changes" by Lykke Boysen. Supervisors: Jens Lykkesfeldt, KU-SUND, Brian Lauritzen, Anne Ejrnæs Sprinkel and Johan Forsell, Novo Nordisk. PhD fellowship initiated 1 November 2015.

Start 2016
"The effect of diet-induced obesity on differential metabolic responses in rats and mice" by Hannah Zakariassen. Supervisors: Jens Lykkesfeldt, KU-SUND, Linu Mary John, Kirsten Raun, Novo Nordisk. PhD fellowship inititated 1 March 2016.

"Factors driving the variation in absorption of subcutaneously administered insulins" by Anna Katrina Olsen. Supervisors: Jens Lykkesfeldt, KU-SUND, Hanne Refsgaard, Trine Porsgaard, Sanne Gram-Nielsen, Torben Seested Johansen, Novo Nordisk. PhD fellowship initiated 1 March 2016.

"In Vivo characterization of critical determinants of bleeding in the development of heamophilic arhtropathy in the F8-KO rat" by Kåre Kryger Vøls. Supervisors: Axel Kornerup Hansen, KU-SUND, Mads Kjelgaard-Hansen, Kristine Roepstorff, Novo Nordisk. PhD fellowship initiated 1 August 2016.

"Effects of insulin treatment on NAFLD in diabetic rodents" by Victoria Svop Jensen. Supervisors: Jens Lykkesfeldt, KU-SUND, Christian Fledelius, Henning Hvid, Novo Nordisk. PhD fellowship initated 1 September 2016.