Publications – University of Copenhagen

Forward this page to a friend Resize Print Bookmark and Share

LIFEPHARM > Publications

Publications


LIFEPHARM's Professors, Post docs and PhD students has produced the following publications since Oct. 2010.

LIFEPHARM Publications 2016

 

L-dehydroascorbic acid can substitute L-ascorbic acid as dietary vitamin C source in guinea pigs. / Frikke-Schmidt, Henriette Rønne; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens. Redox Biology, Vol. 7, 2016, s. 8-13.

Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model. / Atkinson, Sara Marie; Bleil, Janine; Maier, Rene; Kuehl, Anja A.; Thorn, Mette; Serikawa, Kyle; Fox, Brian; Kruse, Kim; Haase, Claus; Skov, Soren; Nansen, Anneline; Syrbe, Uta. Arthritis Research & Therapy, Vol. 18, 28, 23.01.2016.

Antibody response to recombinant human coagulation factor VIII in a new rat model of severe hemophilia A. / Löfgren, Karin Maria; Sondergaard, H.; Skov, Søren; Weldingh, K. N.; Tranholm, M.; Wiinberg, B. Journal of Thrombosis and Haemostasis, Vol. 14, Nr. 4, 04.2016, s. 747-756.

Breeding Restrictions Decrease the Prevalence of Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels over an 8-to 10-Year Period. / Birkegård, Anna Camilla; Reimann, M. J.; Martinussen, T.; Haggstrom, J.; Pedersen, H. D.; Olsen, Lisbeth Høier. Journal of Veterinary Internal Medicine, Vol. 30, Nr. 1, 2016, s. 63-68.

Changes in heart rate, arrhythmia frequency, and cardiac biomarker values in horses during recovery after a long-distance endurance ride. / Madsen, Mette Flethøj; Kanters, Jørgen K.; Haugaard, Maria Mathilde; Pedersen, Philip Juul; Carstensen, Helena; Balling, Johanne D.; Olsen, Lisbeth Høier; Buhl, Rikke. American Veterinary Medical Association. Journal, Vol. 248, Nr. 9, 01.05.2016, s. 1034-1042.

Depletion of regulatory T cells leads to an exacerbation of delayedtype hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade. / Atkinson, Sara Marie; Hoffmann, Ute; Bach, Emil; Danneskiold-Samsøe, Niels Banhos; Kristiansen, Karsten; Serikawa, Kyle ; Fox, Brian ; Kruse, Kim; Haase, Claus; Skov, Søren; Nansen, Anneline. Disease Models & Mechanisms, Vol. 9, 2016, s. 427-440.

Diet-induced dyslipidemia leads to nonalcoholic fatty liver disease and oxidative stress in guinea pigs. / Tveden-Nyborg, Pernille; Birck, Malene Muusfeldt; Ipsen, David Højland; Thiessen, Tina Salløe; Feldmann, Linda de Bie; Lindblad, Maiken Marie; Jensen, Henrik Elvang; Lykkesfeldt, Jens. Translational Research, Vol. 168, 01.02.2016, s. 146-160.

Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies. Ekkelund Petersen, Karen; Rakipovski, Günaj; Raun, Kirsten; Lykkesfeldt, Jens. Current Diabetes Reviews, 2016, 12, 331-358.

Dyslipidemia: Obese or Not Obese-That Is Not the Question. Ipsen DH, Tveden-Nyborg P, Lykkesfeldt J. Curr Obes Rep. 2016 Dec;5(4):405-412. 

High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs. / Ipsen, David Højland; Tveden-Nyborg, Pernille; Rolin, Bidda; Rakipovski, Günaj; Beck, Maria; Mortensen, Line Winther; Færk, Lasse; Heegaard, Peter Mikael Helweg; Møller, Peter; Lykkesfeldt, Jens. Nutrition & Metabolism, Vol. 13, 2016, s. 51. 

Histopathological nerve and skeletal muscle changes in rats subjected to persistent insulin-induced hypoglycemia. / Jensen, Vivi Flou Hjorth; Mølck, Anne-Marie; Heydenreich, Annette; Jensen, Karin Juul; Bertelsen, Line Olrik; Alifrangis, Lene; Andersen, Lene; Søeborg, Henrik; Chapman, Melissa; Lykkesfeldt, Jens; Bøgh, Ingrid Brück. Toxicologic Pathology, Vol. 29, Nr. 1, 01.2016, s. 17-30.

Increased serum C-reactive protein concentrations in dogs with congestive heart failure due to myxomatous mitral valve disease. / Reimann, M. J.; Ljungvall, I.; Hillstrom, A.; Møller, J. E.; Hagman, R.; Falk, T.; Hoglund, K.; Haggstrom, J.; Olsen, Lisbeth Høier. Veterinary Journal, Vol. 209, 03.2016, s. 113-118.

Joint bleeds increase the inhibitor response to human factor VIII in a rat model of severe haemophilia A. / Löfgren, Karin Maria; Søndergaard, H.; Skov, Søren; Wiinberg, B. Haemophilia, Vol. 22, Nr. 5, 09.2016, s. 772-779.

Maternal vitamin C deficiency does not reduce hippocampal volume and beta-tubulin III intensity in prenatal Guinea pigs. / Hansen, Stine Normann; Schjoldager, Janne Gram; Paidi, Maya Devi; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille. Nutrition Research, Vol. 36, Nr. 7, 07.2016, s. 696-702.

Modulating the gut microbiota improves glucose tolerance, lipoprotein profile and atherosclerotic plaque development in ApoE-deficient mice. / Rune, Ida; Rolin, Bidda; Larsen, Christian Schiøth; Nielsen, Dennis Sandris; Kanter, Jenny E.; Bornfeldt, Karin E.; Lykkesfeldt, Jens; Buschard, Karsten; Kirk, Rikke Kaae; Christoffersen, Berit; Fels, Johannes Josef; Josefsen, Knud; Kihl, Pernille; Hansen, Axel Kornerup. P L o S One, Vol. 11, Nr. 1, e0146439, 2016.

Normal weight dyslipidemia: Is it all about the liver? D Højland Ipsen, P Tveden‐Nyborg, J Lykkesfeldt. Volume 24, Issue 3, March 2016,  Pages 556–567

Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance. / Jothery, Aqeel H. Al; Vaanholt, Lobke M.; Mody, Nimesh; Arnous, Anis; Lykkesfeldt, Jens; Bunger, Lutz; Hill, William G.; Mitchell, Sharon E.; Allison, David B.; Speakman, John R. Scientific Reports, Vol. 6, 36353 , 14.11.2016.

Penetration of antimicrobials to pulmonary epithelial lining fluid and muscle and impact of drug physicochemical properties determined by microdialysis. / Rottbøll, Lisa Amanda Holm; Friis, Christian. Journal of Pharmacological and Toxicological Methods, Vol. 78, 2016, s. 58-65.

Reduced Mechanical Stretch Induces Enhanced Endothelin B Receptor-mediated Contractility via Activation of Focal Adhesion Kinase and Extra Cellular-regulated Kinase 1/2 in Cerebral Arteries from Rat. / Rasmussen, Marianne N P; Spray, Stine; Skovsted, Gry F; Warfvinge, Karin; Sheykhzade, Majid; Edvinsson, Lars. Basic & Clinical Pharmacology & Toxicology Online, Vol. 119, Nr. 1, 19.01.2016, s. 68-77.

Rodent model choice has major impact on variability of standard preclinical readouts associated with diabetes and obesity research. / Jensen, Victoria Svop; Porsgaard, Trine ; Lykkesfeldt, Jens; Hvid, Henning . American Journal of Translational Research, Vol. 8, Nr. 8, 15.08.2016, s. 3574-3584.

Similar Adiponectin Levels in Obese Normotensive and Obese Hypertensive Men and No Vasorelaxant Effect of Adiponectin on Human Arteries. / Dreier, Rasmus; Asferg, Camilla; Berg, Jais O; Andersen, Ulrik B; Flyvbjerg, Allan; Frystyk, Jan; Linneberg, Allan; Jeppesen, Jørgen L; Edvinsson, Lars; Skovsted, Gry F. Basic & Clinical Pharmacology & Toxicology, Vol. 118, Nr. 2, 02.2016, s. 128–135 .

Simultaneous quantification of monoamine neurotransmitters and their biogenic metabolites intracellularly and extracellularly in primary neuronal cell cultures and in sub-regions of guinea pig brain. / Schou-Pedersen, Anne Marie Voigt; Hansen, Stine Normann; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, Vol. 1028, 15.08.2016, s. 222-230.

Simvastatin and oxidative stress in humans : A randomized, double-blinded, placebo-controlled clinical trial. / Rasmussen, Sanne Tofte; Andersen, Jon Thor Trærup; Nielsen, Torben Kjær; Cejvanovic, Vanja; Petersen, Kasper Meidahl; Henriksen, Trine; Weimann, Allan; Lykkesfeldt, Jens; Poulsen, Henrik Enghusen. Redox Biology, Vol. 9, 2016, s. 32-38.

Strategies for Using Plagiarism Software in the Screening of Incoming Journal Manuscripts : Recommendations Based on a Recent Literature Survey. / Lykkesfeldt, Jens. Basic & Clinical Pharmacology & Toxicology, Vol. 119, Nr. 2, 08.2016, s. 161-164.

The F8(-/-) rat as a model of hemophilic arthropathy. / Christensen, Kristine Rothaus; Roepstorff, K.; Wiinberg, B.; Hansen, Axel Kornerup; Tranholm, M.; Nielsen, L. N.; Kjelgaard-Hansen, M.  Journal of Thrombosis and Haemostasis, Vol. 14, Nr. 6, 06.2016, s. 1216-1225.

The kidneys play a central role in the clearance of rhGH in rats. / Vestergaard, Bill; Thygesen, Peter; Kreilgaard, Mads; Fels, Johannes Josef; Lykkesfeldt, Jens; Agerso, Henrik. European Journal of Pharmaceutical Sciences, Vol. 86, 30.04.2016, s. 29-33.

 

LIFEPHARM Publications 2015

Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease. / Cremer, Signe Emilie; Moesgaard, S. G.; Rasmussen, C. E.; Zois, N. E.; Falk, T.; Reimann, Maria Josefine; Cirera Salicio, Susanna; Aupperle, H.; Oyama, M. A.; Olsen, Lisbeth Høier. I: Research in Veterinary Science, Vol. 100, 19.03.2015, s. 197-206.

Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics : a case-control study. / Jørgensen, Anders; Knorr, Ulla Benedichte Søsted; Soendergaard, Mia Greisen; Lykkesfeldt, Jens; Fink-Jensen, Anders; Poulsen, Henrik Enghusen; Jørgensen, Martin Balslev; Olsen, Niels Vidiendal; Staalsø, Jonatan Myrup. I: B M C Psychiatry, Vol. 15, 67, 2015.

Colonic lesions, cytokine profiles, and gut microbiota in plasminogen-deficient mice. / Vestergaard, Bill; Krych, Lukasz; Lund, Leif R; Jørgensen, Bettina Merete Pyndt; Hansen, Lars H.; Jensen, Henrik Elvang; Nielsen, Dennis Sandris; Hansen, Axel Kornerup. I: Comparative Medicine (Memphis), Vol. 65, Nr. 5, 2015, s. 382-397.

Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults. / Hemmingsen, Jette Gjerke; Rissler, Jenny; Lykkesfeldt, Jens; Sallsten, Gerd; Kristiansen, Jesper; Møller, Peter; Loft, Steffen. I: Particle and Fibre Toxicology, Vol. 12, 6, 2015.

Depletion of regulatory T cells in a hapten-induced inflammation model results in prolonged and increased inflammation driven by T cells. / Christensen, A. D.; Skov, Søren; Kvist, P. H.; Haase, C. I: Clinical and Experimental Immunology, Vol. 179, Nr. 3, 03.2015, s. 485-499.

Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice. / Jørgensen, Bettina Merete Pyndt; Winther, Gudrun; Kihl, Pernille; Nielsen, Dennis Sandris; Wegener, Gregers; Hansen, Axel Kornerup; Sørensen, Dorte Bratbo. I: Acta Neuropsychiatrica (Print), Vol. 27, Nr. 5, 2015, s. 307-311.

Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour. / Winther, Gudrun; Jørgensen, Betina M. Pyndt; Elfving, Betina; Nielsen, Dennis Sandris; Kihl, Pernille; Lund, Sten; Sørensen, Dorte Bratbo; Wegener, Gregers. I: Acta Neuropsychiatrica (Print), Vol. 27, Nr. 3, 2015, s. 168-176.

Distribution of vitamin C is tissue specific with early saturation of the brain and adrenal glands following differential oral dose regimens in guinea pigs. / Andersen, Stine Hasselholt; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens. I: British Journal of Nutrition, Vol. 113, Nr. 10, 2015, s. 1539-1549.

Elimination of ascorbic acid after high-dose infusion in prostate cancer patients : a pharmacokinetic evaluation. / Nielsen, Torben Kjær; Højgaard, Martin; Andersen, Jon Thor Trærup; Poulsen, Henrik Enghusen; Lykkesfeldt, Jens; Mikines, Kari Joensen. I: Basic & Clinical Pharmacology & Toxicology, Vol. 116, Nr. 4, 2015, s. 343-348.

Endothelin-1 and endothelin-3 regulate endothelin receptor expression in rat coronary arteries. / Skovsted, Gry Freja; Kilic, Semsi; Edvinsson, Lars. I: Basic & Clinical Pharmacology & Toxicology Online, Vol. 117, Nr. 5, 2015, s. 297-305.

Göttingen minipig model of diet-induced atherosclerosis : influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals. / Ludvigsen, Trine Pagh; Kirk, Rikke Kaae; Christoffersen, Berit Østergaard; Pedersen, Henrik Duelund; Martinussen, Torben; Kildegaard, Jonas ; Heegaard, Peter M. H.; Lykkesfeldt, Jens; Olsen, Lisbeth Høier. I: Journal of Translational Medicine, Vol. 13, 312, 2015.

High-resolution gene expression profiling using RNA sequencing in patients with inflammatory bowel disease and in mouse models of colitis. / Holgersen, Kristine; Kutlu, Burak; Fox, Brian ; Serikawa, Kyle; Lord, James; Hansen, Axel Kornerup; Holm, Thomas Lindebo. I: Journal of Crohn's and Colitis (JCC), Vol. 9, Nr. 6, 03.2015, s. 492-506.

IL-33 promotes GATA-3 polarization of gut-derived T cells in experimental and ulcerative colitis. / Seidelin, Jakob Benedict; Coskun, Mehmet; Kvist, Peter Helding; Holm, Thomas Lindebo; Holgersen, Kristine; Nielsen, Ole Haagen. I: Journal of Gastroenterology, Vol. 50, Nr. 2, 2015, s. 180-190.

Intrabronchial microdialysis : effects of probe localization on tissue trauma and drug penetration into the pulmonary epithelial lining fluid. / Rottbøll, Lisa Amanda Holm; Skovgaard, Kerstin; Barington, Kristiane; Jensen, Henrik Elvang; Friis, Christian. I: Basic & Clinical Pharmacology & Toxicology, Vol. 117, Nr. 4, 2015, s. 242-250.

Lower limb ischaemia and reperfusion injury in healthy volunteers measured by oxidative and inflammatory biomarkers. / Halladin, N. L.; Busch, Sarah Victoria Ekeløf; Alamili, M.; Bendtzen, K.; Lykkesfeldt, Jens; Rosenberg, Jacob; Gögenür, Ismayil. I: Perfusion, Vol. 30, Nr. 1, 10.04.2015, s. 64-70.

Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs. / Schjoldager, Janne Gram; Paidi, Maya Devi; Lindblad, Maiken Marie; Birck, Malene Muusfeldt; Kjærgaard, Astrid Birch; Dantzer, Vibeke; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille. I: European Journal of Nutrition, Vol. 54, Nr. 4, 2015, s. 667-676.

Piroxicam treatment augments bone abnormalities in interleukin-10 knockout mice. / Holgersen, Kristine; Dobie, Ross; Farquharson, Colin; Van't Hof, Rob ; Ahmed, Syed Faisal ; Hansen, Axel Kornerup; Lindebo Holm, Thomas. I: Inflammatory Bowel Diseases, Vol. 21, Nr. 2, 02.2015, s. 257-266.

Plasma and serum serotonin concentrations and surface-bound platelet serotonin expression in Cavalier King Charles Spaniels with myxomatous mitral valve disease. / Cremer, Signe Emilie; Kristensen, Annemarie Thuri; Reimann, Maria Josefine; Eriksen, Nynne B.; Petersen, Stine F.; Marschner, Clara Büchner; Tarnow, Inge; Oyama, Mark A.; Olsen, Lisbeth Høier. I: American Journal of Veterinary Research, Vol. 76, Nr. 6, 2015, s. 520-531.

Serotonin markers show altered transcription levels in an experimental pig model of mitral regurgitation. / Cremer, Signe Emilie; Zois, Nora Elisabeth; Moesgaard, S. G. ; Ravn, Nathja; Cirera Salicio, Susanna; Honge, J. L.; Smerup, Morten Holdgaard; Hasenkam, J. Michael; Sloth, E.; Leifsson, Páll S.; Falk, Bo Torkel; Oyama, M. A.; Orton, C.; Martinussen, Torben; Olsen, Lisbeth Høier. I: The Veterinary Journal, Vol. 203, Nr. 2, 2015, s. 192-198.

The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection : a pilot study. / Skov, Marianne; Pressler, Tacjana; Lykkesfeldt, Jens; Poulsen, Henrik Enghusen; Østrup Jensen, Peter; Johansen, Helle Krogh; Qvist, Tavs; Kræmer, Dorthe; Høiby, Niels; Ciofu, Oana. I: Journal of Cystic Fibrosis, Vol. 14, Nr. 2, 03.2015, s. 211-218.

The influence of the young microbiome on inflammatory diseases - lessons from animal studies. / Bendtsen, Katja Maria Bangsgaard; Fisker, Line; Hansen, Axel Kornerup; Hansen, Camilla Hartmann Friis; Nielsen, Dennis Sandris. I: Birth Defects Research. Part C: Embryo Today Reviews, Vol. 105, Nr. 4, 2015, s. 278-295.

Thick methacrylate sections devoid of lost caps simplify stereological quantifications based on the optical fractionator design. / Andersen, Stine Hasselholt; Lykkesfeldt, Jens; Larsen, Jytte Overgaard. I: Anatomical Record, Vol. 298, Nr. 12, 15.09.2015, s. 2141-2150.

Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model. / Atkinson, Sara Marie; Nansen, Anneline; Usher, Pernille A.; Sondergaard, Bodil-Cecilie; Mackay, Charles R.; Friedrichsen, Birgitte; Chang, Chih-Chuan; Tang, Renhong; Skov, Søren; Haase, Claus; Hornum, Lars. I: Autoimmunity, Vol. 48, Nr. 7, 11.2015, s. 460-470.

LIFEPHARM Publications 2014

Antioxidant supplementation for lung disease in cystic fibrosis. / Ciofu, Oana; Lykkesfeldt, Jens. The Cochrane library, Vol. 2014, Nr. 8, CD007020, 2014.

Associations between N-terminal procollagen type III, fibrosis and echocardiographic indices in dogs that died due to myxomatous mitral valve disease. / Hezzell, Melanie J.; Falk, Bo Torkel; Olsen, Lisbeth Høier; Boswood, Adrian; Elliott, Jonathan. Journal of Veterinary Cardiology, Vol. 16, Nr. 4, 2014, s. 257-264.

Biodistribution of rhodamine B fluorescence-labeled cationic nanoparticles in rats. / Knudsen, Kristina Bram; Northeved, Helle; Gjetting, Torben; Permin, Anders ; Andresen, Thomas Lars; Wegener, Karen Malene; Rye Lam, Henrik ; Lykkesfeldt, Jens. Journal of Nanoparticle Research, Vol. 16, Nr. 1, 2221, 2014.

Biopterin status in dogs with myxomatous mitral valve disease is associated with disease severity and cardiovascular risk factors. / Reimann, Maria Josefine; Häggström, J.; Mortensen, Alan; Lykkesfeldt, Jens; Møller, Jacob Eifer; Falk, Bo Torkel; Olsen, Lisbeth Høier. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 28, Nr. 5, 2014, s. 1520-1526.

Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse : a model mimicking inflammatory bowel disease. / Holgersen, Kristine; Kvist, Peter Helding ; Markholst, Helle; Hansen, Axel Jacob Kornerup; Holm, Thomas Lindebo. Journal of Crohn's and Colitis, Vol. 8, Nr. 2, 2014, s. 147-160.

Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. / Paidi, Maya Devi; Schjoldager, Janne Gram; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille. Nutrients, Vol. 6, Nr. 5, 2014, s. 1809-1822.

Development of left ventricular hypertrophy in a novel porcine model of mitral regurgitation. / Ravn, Nathja; Zois, Nora Elisabeth; Moesgaard, Sophia G.; Hønge, Jesper Langhoff; Smerup, Morten Holdgaard; Hasenkam, J. Michael; Sloth, Erik; Cremer, Signe Emilie; Olsen, Lisbeth Høier. Scandinavian Cardiovascular Journal, Vol. 48, Nr. 3, 2014, s. 189-195.

Differential toxicological response to positively and negatively charged nanoparticles in the rat brain. / Knudsen, Kristina Bram; Northeved, Helle; Ek, Pramod Kumar; Permin, Anders; Andresen, Thomas Lars; Larsen, Steen; Wegener, Karen Malene; Lam, Henrik Rye; Lykkesfeldt, Jens. Nanotoxicology, Vol. 8, Nr. 7, 2014, s. 764-774.

Does vitamin C deficiency affect cognitive development and function?. / Hansen, Stine Normann; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens. Nutrients, Vol. 6, Nr. 9, 2014, s. 3818-3846.

Effect of insulin-induced hypoglycaemia on the central nervous system : evidence from experimental studies. / Jensen, Vivi Flou Hjorth; Bøgh, I. B.; Lykkesfeldt, Jens. Journal of Neuroendocrinology, Vol. 26, Nr. 3, 2014, s. 123-150.

Effect of insulin-induced hypoglycaemia on the peripheral nervous system : focus on adaptive mechanisms, pathogenesis and histopathological changes. / Jensen, Vivi Flou Hjorth; Mølck, A.-M.; Bøgh, I. B.; Lykkesfeldt, Jens. Journal of Neuroendocrinology, Vol. 26, Nr. 8, 2014, s. 482-496.

Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs. / Boonen, Harrie C.M.; Moesgaard, Sophia Gry; Birck, Malene Muusfeldt; Christoffersen, Berit Østergaard; Cirera Salicio, Susanna; Heegaard, Peter M. H.; Højbøge, Tina Rødgaard; Jensen, Lars Jørn; Mortensen, Alan; Olsen, Lisbeth Høier; Sheykhzade, Majid; Tang, Jiaowei; Lykkesfeldt, Jens. Pflügers ARchiv (European Journal of Physiology), Vol. 466, Nr. 12, 2014, s. 2167-2176.

High-fat feeding increases hepatic vitamin C synthesis and its circulatory mobilization in mice. / Christensen, Britt Tranberg; Hansen, Axel Jacob Kornerup; Lykkesfeldt, Jens. European Journal of Nutrition, Vol. 53, Nr. 6, 2014, s. 1441-1444.

Holter monitoring of small breed dogs with advanced myxomatous mitral valve disease with and without a history of syncope. / Rasmussen, Caroline Elisabeth; Falk, Bo Torkel; Petrič, A. Domanjko; Schaldemose, Maja; Zois, Nora Elisabeth; Moesgaard, S. G.; Åblad, B.; Nielsen, H. Y.; Ljungvall, I.; Höglund, K.; Häggström, J.; Pedersen, H. D.; Bland, J. M.; Olsen, Lisbeth Høier. Journal of Veterinary Internal Medicine, Vol. 28, Nr. 2, 2014, s. 363-370.

Increased Contracaecum osculatum infection in baltic cod (Gadus morhua) livers (1982-2012) associated with increasing grey seal (Halichoerus gryphus) populations. Haarder S, Kania PW, Galatius A, Buchmann K. J Wildl Dis. 2014 Jul;50(3):537-43 Epub 2014 Apr 29. Int Immunopharmacol. 2014 Jul;21(1):137-47.

In vivo vitamin C deficiency in guinea pigs increases ascorbate transporters in liver but not kidney and brain. / Søgaard, Ditte; Lindblad, Maiken Marie; Paidi, Maya Devi; Andersen, Stine Hasselholt; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille. Nutrition Research, Vol. 34, Nr. 7, 2014, s. 639-645.

Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs. / Schjoldager, Janne Gram; Paidi, Maya Devi; Lindblad, Maiken Marie; Birck, Malene Muusfeldt; Kjærgaard, Astrid Birch; Dantzer, Vibeke; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille. European Journal of Nutrition, 04.12.2014, s. 1-12.

Matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) and transforming growth factor-β (TGF-β) in advanced canine myxomatous mitral valve disease. / Moesgaard, S. G.; Aupperle, H.; Rajamäki, M. M.; Falk, T.; Rasmussen, C. E.; Zois, Nora Elisabeth; Olsen, Lisbeth Høier. Research in Veterinary Science, Vol. 97, Nr. 3, 2014, s. 560-567.

Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. / Halladin, Natalie L.; Busch, Sarah Victoria Ekeløf; Jensen, Svend Eggert; Aarøe, Jens; Kjærgaard, Benedict; Heegaard, Peter M. H.; Lykkesfeldt, Jens; Rosenberg, Jacob; Gögenür, Ismayil. In Vivo, Vol. 28, 2014, s. 483-488.

Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model. / Alamili, Mahdi; Bendtzen, Klaus; Lykkesfeldt, Jens; Rosenberg, Jacob; Gögenür, Ismayil. Journal of Critical Care, Vol. 29, Nr. 1, 2014, s. 184.e9-184.e13.

Microdialysis as a tool for drug quantification in the bronchioles of anaesthetized pigs. / Rottbøll, Lisa Amanda Holm; Friis, Christian. Basic & Clinical Pharmacology & Toxicology Online, Vol. 114, Nr. 3, 2014, s. 226-232.

Noninvasive assessment of pulse-wave velocity and flow-mediated vasodilation in anesthetized Göttingen minipigs. / Ludvigsen, Trine Pagh; Wiinberg, Niels; Jensen, Christina J.; Callesen, Annemette T.; Andersen, Regitze W.; Jørgensen, Anne Sofie H.; Christoffersen, Berit Ø.; Pedersen, Henrik D.; Moesgaard, Sophia Gry; Olsen, Lisbeth Høier. Comparative Medicine (Memphis), Vol. 64, Nr. 6, 2014, s. 471-477.

Non-terminal blood sampling techniques in Guinea pigs. Malene Muusfeldt Birck, Pernille Tveden-Nyborg, Maiken Marie Lindblad, Jens Lykkesfeldt. Jove-Journal of visualized experiments, Video article. 2014.

Predictive validity and immune cell involvement in the pathogenesis of piroxicam-accelerated colitis in interleukin-10 knockout mice. / Holgersen, Kristine; Kvist, Peter Helding; Hansen, Axel Jacob Kornerup; Holm, Thomas Lindebo. International Immunopharmacology, Vol. 21, Nr. 1, 2014, s. 137-147.

Prenatal vitamin C deficiency results in differential levels of oxidative stress during late gestation in foetal guinea pig brains. / Paidi, Maya Devi; Schjoldager, Janne Gram; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille. Redox Biology, Vol. 2, 2014, s. 361-367.

Pronounced inflammatory response to endotoxaemia during nighttime : a randomised cross-over trial. / Alamili, Mahdi; Bendtzen, Klaus; Lykkesfeldt, Jens; Rosenberg, Jacob; Gögenur, Ismail. PloS one, Vol. 9, Nr. 1, e87413, 2014.

R-R interval variations influence the degree of mitral regurgitation in dogs with myxomatous mitral valve disease. / Reimann, Maria Josefine; Møller, Jacob Eifer; Häggström, Jens; Markussen, Bo; Holen, Astrid Elisabeth Walvik; Falk, Bo Torkel; Olsen, Lisbeth Høier. The Veterinary Journal, Vol. 199, Nr. 3, 2014, s. 348-354.

Serotonin concentrations in platelets, plasma, mitral valve leaflet, and left ventricular myocardial tissue in dogs with myxomatous mitral valve disease. / Cremer, Signe Emilie; Singletary, G.E.; Olsen, Lisbeth Høier; Wallace, K.; Häggström, J.; Ljungvall, I.; Höglund, K.; Reynolds, C.A.; Pizzinat, N.; Oyama, M.A. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 28, Nr. 5, 2014, s. 1534-1540.

The kidneys play an important role in the clearance of rFVIIa in rats. / Vestergaard, Bill; Appa, Rupa S.; Lykkesfeldt, Jens; Agersø, Henrik. Thrombosis Research, Vol. 133, Nr. 6, 2014, s. 1124-1129.

The role of neutrophils and G-CSF in DNFB-induced contact hypersensitivity in mice. / Christensen, Anne Deen; Skov, Søren; Haase, Claus. Immunity, Inflammation and Disease, Vol. 2, Nr. 1, 2014, s. 21-34.

Transfer of gut microbiota from lean and obese mice to antibiotic-treated mice. / Ellekilde, Merete; Selfjord, Ellika Marie; Larsen, Christian S.; Jakesevic, Maja; Rune, Ida; Christensen, Britt Tranberg; Vogensen, Finn Kvist; Nielsen, Dennis Sandris; Bahl, Martin Iain; Licht, Tine Rask; Hansen, Axel Jacob Kornerup; Hansen, Camilla Hartmann Friis. Scientific Reports, Vol. 4, 5922, 2014.

Vitamin C. / Lykkesfeldt, Jens; Michels, Alexander J.; Frei, Balz. Advances in Nutrition, Vol. 5, Nr. 1, 2014, s. 16-18.

LIFEPHARM Publications 2013

Ampicillin-improved glucose tolerance in diet-induced obese C57BL/6NTac mice is age dependent. / Rune, Ida; Hansen, Camilla Hartmann Friis; Ellekilde, Merete; Nielsen, Dennis Sandris; Skovgaard, K.; Rolin, B.C.; Lykkesfeldt, Jens; Josefsen, K.; Christensen, Britt Tranberg; Kihl, Pernille; Hansen, Axel Jacob Kornerup. Experimental Diabetes Research, Vol. 2013, 319321, 2013.

Cardiac natriuretic peptide gene expression and plasma concentrations during the first 72 hours of life in piglets. / Smith, Julie; Christoffersen, Christina; Nørgaard, Linn Maiken; Olsen, Lisbeth Høier; Vejlstrup, Niels G.; Andersen, Claus Bøgelund; Gøtze, Jens P. Endocrinology, Vol. 154, Nr. 5, 2013, s. 1864-1872.

Cardiac troponin-I concentration, myocardial arteriosclerosis, and fibrosis in dogs with congestive heart failure because of Myxomatous Mitral Valve Disease. / Falk, Bo Torkel; Ljungvall, I.; Zois, Nora Elisabeth; Höglund, K.; Olsen, Lisbeth Høier; Pedersen, H.D.; Häggström, J. Journal of Veterinary Internal Medicine, Vol. 27, Nr. 3, 2013, s. 500-506.

Circadian Variation in the Response to Experimental Endotoxemia and Modulatory Effects of Exogenous Melatonin. / Alamili, Mahdi; Klein, Mads; Lykkesfeldt, Jens; Rosenberg, Jacob; Gögenur, Ismail. Chronobiology International, Vol. 30, Nr. 9, 2013, s. 1174-1180.

Comparative infectivity of three larval nematode species in three different salmonids. Haarder S, Kania PW, Buchmann K. Parasitol Res. 2013 Aug;112(8):2997-3004.

Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass in piglets. / Liuba, Petru; Johansson, Sune; Pesonen, Erkki; Odermarsky, Michal; Hansen, Axel Jacob Kornerup; Forslid, Anders; Aburawi, Elhadi H.; Higgins, Thomas; Birck, Malene Muusfeldt; Perez-de-Sa, Valeria. Journal of Cardiothoracic Surgery, Vol. 8, 157, 2013.

Does vitamin C deficiency increase lifestyle-associated vascular disease progression? : evidence based on experimental and clinical studies. / Tveden-Nyborg, Pernille; Lykkesfeldt, Jens. Antioxidants & Redox Signaling, Vol. 19, Nr. 17, 2013, s. 2084-2104.

Endothelial cell death and intimal foam cell accumulation in the coronary artery of infected hypercholesterolemic minipigs. / Birck, Malene Muusfeldt; Saraste, Antti; Hyttel, Poul; Odermarsky, Michal; Liuba, Petru; Saukko, Pekka; Hansen, Axel Jacob Kornerup; Pesonen, Erkki. Journal of Cardiovascular Translational Research, Vol. 6, Nr. 4, 2013, s. 579-587.

Expression of immune relevant genes in rainbow trout following exposure to live Anisakis simplex larvae. / Haarder, Simon; Kania, Per Walter; Bahlool, Qusay Zuhair Mohammad; Buchmann, Kurt. Experimental Parasitology, Vol. 135, Nr. 3, 2013, s. 564-569.

Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo. / Mortensen, Alan; Andersen, Stine Hasselholt; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens. Nutrition Research, Vol. 33, Nr. 10, 2013, s. 859-867.

Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells. / Hansen, Camilla Hartmann Friis; Holm, Thomas L.; Krych, Lukasz; Andresen, Lars; Nielsen, Dennis Sandris; Rune, Ida; Hansen, Axel Jacob Kornerup; Skov, Søren. European Journal of Immunology, Vol. 43, Nr. 2, 2013, s. 447-457.

Increased systemic oxidatively generated DNA and RNA damage in schizophrenia. / Jørgensen, Anders; Brødbæk, Kasper; Fink-Jensen, Anders; Knorr, Ulla; Greisen Søndergaard, Mia; Henriksen, Trine; Weimann, Allan; Jepsen, Peter; Lykkesfeldt, Jens; Poulsen, Henrik Enghusen; Jørgensen, Martin Balslev. Psychiatry Research, Vol. 209, Nr. 3, 2013, s. 417–423.

Kinetics of acid-induced degradation of tetra- and dihydrobiopterin in relation to their relevance as biomarkers of endothelial function. / Mortensen, Alan; Lykkesfeldt, Jens. Biomarkers, Vol. 18, Nr. 1, 2013, s. 55-62.

Left ventricular twist and circumferential strain in dogs with myxomatous mitral valve disease. / Zois, Nora Elisabeth; Olsen, N. T.; Moesgaard, S. G.; Rasmussen, Caroline Elisabeth; Falk, Bo Torkel; Häggström, J.; Pedersen, H. D.; Møller, J. E.; Olsen, Lisbeth Høier. Journal of Veterinary Internal Medicine, Vol. 27, Nr. 4, 2013, s. 875-883.

Local and systemic effects of co-stimulatory blockade using cytotoxic T lymphocyte antigen-4-immunoglobulin in dinitrofluorobenzene- and oxazolone-induced contact hypersensitivity in mice. / Christensen, A. D.; Skov, Søren; Haase, C. Clinical and Experimental Immunology, Vol. 171, Nr. 2, 2013, s. 220-230.

Nephrectomized and hepatectomized animal models as tools in preclinical pharmacokinetics. / Vestergaard, Bill; Agersø, Henrik; Lykkesfeldt, Jens. Basic & Clinical Pharmacology & Toxicology Online, Vol. 113, Nr. 2, 2013, s. 75-86.

Occurrence of Diplostomum pseudospathaceum Niewiadomska, 1984 and D. mergi Dubois, 1932 (Digenea: Diplostomidae) in Danish freshwater snails: ecological and molecular data. Haarder S, Jørgensen K, Kania PW, Skovgaard A, Buchmann K. Folia Parasitol (Praha). 2013 May;60(2):177-80.

Physiological parameters of endurance horses pre-compared to post-race, correlated with performance : a two race study from Scandinavia. / Larsson, Josefine; Pilborg, P.H.; Johansen, M.; Christophersen, Mogens Teken; Holte, Andreas; Roepstorff, L.; Olsen, Lisbeth Høier; Harrison, Adrian Paul. I S R N Veterinary Science, Vol. 2013, 684353, 2013.

Plasma proANP and SDMA and microRNAs are associated with chronic mitral regurgitation in a pig model. / Cirera Salicio, Susanna; Moesgaard, Sophia G.; Zois, Nora Elisabeth; Ravn, Nathja; Gøtze, Jens Peter; Cremer, Signe Emilie; Teerlink, Tom; Leifsson, Páll S.; Honge, Jesper L.; Hasenkam, J. Michael; Olsen, Lisbeth Høier. Endocrine Connections, Vol. 2, Nr. 3, 2013, s. 161-171.

Prolonged effect of a new O-glycoPEGylated FVIII (N8-GP) in a murine saphenous vein bleeding model. / Pastoft, Anne Engedahl; Ezban, M.; Tranholm, M.; Lykkesfeldt, Jens; Lauritzen, B. Haemophilia Online, Vol. 19, Nr. 6, 2013, s. 913-919.

Prolonged maternal vitamin C deficiency overrides preferential fetal ascorbate transport but does not influence perinatal survival in guinea pigs. / Schjoldager, Janne Gram; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens. British Journal of Nutrition, Vol. 110, Nr. 9, 2013, s. 1573-1579.

Regulation of vitamin C homeostasis during deficiency. / Lindblad, Maiken Marie; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens. Nutrients, Vol. 5, Nr. 8, 2013, s. 2860-2879.

Whey protein reduces early life weight gain in mice fed a high-fat diet. / Christensen, Britt Tranberg; Hellgren, Lars; Lykkesfeldt, Jens; Sejrsen, Kristen; Jeamet, Aymeric; Rune, Ida; Ellekilde, Merete; Nielsen, Dennis Sandris; Hansen, Axel Jacob Kornerup. PLoS ONE, Vol. 8, Nr. 8, 2013.

LIFEPHARM Publications 2012

A sensitive venous bleeding model in haemophilia A mice: effects of two recombinant FVIII (8 and Advate (®)). Pastoft AE, Lykkesfeldt J, Ezban M, Tranholm M, Whinna HC, Lauritzen B. Haemophilia. 2012.

Ascorbate status modulates reticuloendothelial iron stores and response to deferasitox iron chelation in ascorbate-deficient rats. Casey Brewer, Maya Otto-Duessel, Jens Lykkesfeldt, Hanspeter Nick, and John C. Wood. Experimental Hematology, June 2012; 40:820-827.

Chronic Vitamins C Deficiency does not Accelerate Oxidative Stress in Ageing Brains of Guines Pig. Tveden-Nyborg P, Hasselholt S, Miyashita N, Moos T, Poulsen HE, Lykkesfeldt J, Basic Clin Pharmacol Toxocol. Jun. 2012.

Establishment and characterisation of a sustained delayed-type hypersensitivity model with arthritic manifestations in C57BL/6J mice. Atkinson SM, Usher PA, Kvist PH, Markholst H, Haase C, Nansen A. Arthritis Res Ther. 2012 Jun 7;14(3):R134.

Kinetics of acid induced degradation of tetra-and dihydrobiopterin in relation to their relevance as biomarkers of endothelial function. Alan Mortensen and Jens Lykkesfeldt. Informa Healthcare. Sept 2012.

Local and systemic effects of co-stimulatory blockade using cytotoxic T lymphocyte antigen-4-immunoglobulin in dinitroflurobenzene- and oxazolone-induced contract hypersensitivity in mice. Anne Deen Christensen, S. Skov and C. Haase. Clinical and experimental immunology, 2012, 171:220-230.

Gut microbiota composition is correlated to grid floor induced stress and behavior in the BALB/c mouse. Bangsgaard Bendtsen KM, Krych L, Sørensen DB, Pang W, Nielsen DS, Josefsen K, Hansen LH, Sørensen SJ, Hansen AK. PLoS One. 2012;7(10):e46231.  Epub 2012 Oct 2.

Immunological mechanisms of contact hypersensitivity in mice. Anne Deen Christensen, Claus Haase. Review article in Acta Pathologica, Microbiological et Immunologica Scandinavica. Jan. 2012. 120 (11):1-27.

Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. Pernille Tveden Nyborg, Lucile Vogt, Janne G. Schjoldager, Natalie Jeannet, Stine Hasseholt, Maya D. Paidi, Stepahn Christen, Jens Lykkesfeldt. PLOS one. Oct 2012, vol 7, Issue 10.

Oxidative stress response after laparoscopic versus conventional sigmoid resection: A randomized, double-blind clinical trial. Michael Tvilling Madsen, Bülent Kücükakin, Jens Lykkesfeldt, Jacob Rosenberg, Ismail Gögenur. Surg Laparosc Endosc Percutan Tech, vol 22, num 3, June 2012.

Radial and longitudinal strain and strain rate assessed by speckle-tracking echocardiography in dogs with myxomatous mitral valve disease. Zois NE, Tidholm A, Nägga KM, Moesgaard SG, Rasmussen CE, Falk T, Häggström J, Pedersen HD, Åblad B, Nilsen HY, Olsen LH. J Vet Intern Med. 2012 Nov-Dec;26(6):1309-19.

Role of vitamin C and E supplementation on IL-6 in response to training. Yfanti C, Fischer CP, Nielsen S, Akerström T, Nielsen AR, Veskoukis AS, Kouretas D, Lykkesfeldt J, Pilegaard H, Pedersen BK. J Appl Physiol (1985). 2012 Mar;112(6):990-1000.

 
LIFEPHARM Publications 2011

Animal models in pharmacology and toxicology. Meyer O, Svendsen O and Lykkesfeldt J (2011) In: Handbook of Laboratory Animal Science, Vol 2, 3rd Ed. (Hau J Ed.). CRC Press. In Press.

Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells. Frikke-Schmidt H, Roursgaard M, Lykkesfeldt J, Loft S, Nøjgaard JK and Møller P (2011) Toxicol. Lett.

High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs. Frikke-Schmidt H, Tveden-Nyborg P, Birck MM and Lykkesfeldt J (2011) Brit. J. Nutr., 105, 54-61.

Storage-induced increase in biomarkers of oxidative stress and inflammation in non-filtered red cell suspensions. Kücükakin B, Kocak V, Lykkesfeldt J, Nielsen HJ, Magnussen K, Rosenberg J and Gögenur I (2011) Scand J Clin Lab Invest,

The effect of antioxidant supplementation on insulin-sensitivity in response to endurance exercise training. Yfanti C, Nielsen AR, Åkerström T, Nielsen S, Rose AJ, Richter E, Lykkesfeldt J, Fischer CP, and Pedersen BK (2011) Am. J. Physiol.

Vitamin C in human nutrition. Frikke-Schmidt H, Tveden-Nyborg P and Lykkesfeldt J (2011) In: Vitamins for prevention of human diseases (Herrmann W & Obeid R, eds). pp. 323-347.

Vitamin C: its role in brain development and cognition. Hasselholt, S, Tveden-Nyborg P and Lykkesfeldt J In: Nutrition and Cognitive Performance: A Developmental Perspective; Riby L, Smith MA, and Foster JK, eds (2011).